In vitro uptake of /sup 14/C-praziquantel by cestodes, trematodes, and a nematode

Journal Article · Mon Dec 01 00:00:00 EST 1980 · J. Parasitol.; (United States)

OSTI ID:5639496

Andrews, P; Thomas, H; Weber, H

/sup 14/C-praziquantel was rapidly taken up by Schistosoma mansoni, Fasciola hepatica, Hymenolepis nana, and isolated strobilocerci of Taenia taeniaeformis. Schistosoma mansoni lost praziquantel rapidly to drug-free medium. Chromatography of extracts prepared after incubation of S. mansoni and H. nana yielded no indication that praziquantel was metabolized. Autoradiography revealed a uniform distribution of praziquantel throughout the tissues of S. mansoni and H. nana. Uptake was considerably slower in the nematode Heterakis spumosa and apparently via the oral route.

• OSTI ID: 5639496
• Journal Information: J. Parasitol.; (United States), Vol. 66:6
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
CARBON 14 COMPOUNDS
TRACER TECHNIQUES
QUINOLINES
METABOLISM
AUTORADIOGRAPHY
CESTODES
IN VITRO
NEMATODES
TREMATODES
UPTAKE
ASCHELMINTHES
AZINES
HELMINTHS
HETEROCYCLIC COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PLATYHELMINTHS
PYRIDINES
550201* - Biochemistry- Tracer Techniques
550600 - Medicine