Diagnosis of osteomyelitis and soft tissue infection using a Tc-99m labeled tuftsin-analog peptide
- Brookhaven National Lab., Upton, NY (United States); and others
The localization of infection sites and of osteomyelitis is still an ongoing diagnostic challenge. In joints affected by arthritis, complicated fractures and around prosthetic devices, three-phase bone scans are non-diagnostic because the underlying condition will cause the third phase scan to be positive, while surrounding soft tissue inflammation may cause the first and second phase scans to be positive as well. Currently, the method of choice in these situations is to use radiolabeled white blood cell scans involving lengthy and expensive procedure and need for delayed imaging. We describe a method using a Tc-99m labeled leukotactic peptide for imaging osteomyelitis and soft tissue infections, which appears to be simpler, and enabling fast diagnosis. Abscesses, clean fractures and infected fractures simulating osteomyelitis were induced in rabbits as described earlier. RMT-1, a tuftsin-mimetic synthetic tetrapeptide labeled with Tc-99m was used. Blood clearance, urine excretion and whole body timed scintigraphy were carried out in normal dogs and evaluation of the compound was performed in dogs and rabbits with soft tissue chemical and bacterial abscesses and in rabbits with clean fractures and experimental osteomyelitis.
- Research Organization:
- Brookhaven National Lab. (BNL), Upton, NY (United States)
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 563344
- Report Number(s):
- CONF-970602-; ISSN 0161-5505; TRN: 97:004028-0016
- Journal Information:
- Journal of Nuclear Medicine, Vol. 38, Issue Suppl.5; Conference: 44. annual meeting of the Society of Nuclear Medicine, San Antonio, TX (United States), 2-5 Jun 1997; Other Information: PBD: May 1997
- Country of Publication:
- United States
- Language:
- English
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