Comparison of indium-labeled-leukocyte imaging with sequential technetium-gallium scanning in the diagnosis of low-grade musculoskeletal sepsis. A prospective study

Journal Article · Fri Mar 01 00:00:00 EST 1985 · J. Bone Jt. Surg., Am. Vol.; (United States)

OSTI ID:5553306

Merkel, K D; Brown, M L; Dewanjee, M K; Fitzgerald, Jr, R H

We prospectively compared sequential technetium-gallium imaging with indium-labeled-leukocyte imaging in fifty patients with suspected low-grade musculoskeletal sepsis. Adequate images and follow-up examinations were obtained for forty-two patients. The presence or absence of low-grade sepsis was confirmed by histological and bacteriological examinations of tissue specimens taken at surgery in thirty of the forty-two patients. In these thirty patients, the sensitivity of sequential Tc-Ga imaging was 48 per cent, the specificity was 86 per cent, and the accuracy was 57 per cent, whereas the sensitivity of the indium-labeled-leukocyte technique was 83 per cent, the specificity was 86 per cent, and the accuracy was 83 per cent. When the additional twelve patients for whom surgery was deemed unnecessary were considered, the sensitivity of sequential Tc-Ga imaging was 50 per cent, the specificity was 78 per cent, and the accuracy was 62 per cent, as compared with a sensitivity of 83 per cent, a specificity of 94 per cent, and an accuracy of 88 per cent with the indium-labeled-leukocyte method. In patients with a prosthesis the indium-labeled-leukocyte image was 94 per cent accurate, compared with 75 per cent accuracy for sequential Tc-Ga imaging. Statistical analysis of these data demonstrated that the indium-labeled-leukocyte technique was superior to sequential Tc-Ga imaging in detecting areas of low-grade musculoskeletal sepsis.

• Research Organization: Mayo Clinic, Rochester, MN
• OSTI ID: 5553306
• Journal Information: J. Bone Jt. Surg., Am. Vol.; (United States), Vol. 67:3
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
BIOMEDICAL RADIOGRAPHY
COMPARATIVE EVALUATIONS
MUSCLES
INFLAMMATION
SCINTISCANNING
SKELETON
FEMALES
GALLIUM ISOTOPES
INDIUM ISOTOPES
LABELLING
LEUKOCYTES
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OSTEOMYELITIS
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COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
ISOTOPES
MATERIALS
MEDICINE
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PYRIDINES
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550601* - Medicine- Unsealed Radionuclides in Diagnostics