/sup 125/I-Clq-binding and specific antibodies as indicators of pulmonary disease activity in cystic fibrosis
We studied the incidence and levels of circulating immune complexes by the /sup 125/I-Clq-binding assay in patients with cystic fibrosis in relation to clinical respiratory status and specific IgG and IgE antibodies to Pseudomonas aeruginosa. Staphylococcus aureus, Aspergillus fumigatus, and Candida albicans. Overall prevalence of CIC was 43%, but 86% of serially studied patients had evidence of CIC at some time. Patients with acute respiratory exacerbations and deteriorating pulmonary function had a higher incidence of CIC (76%) as compared to stable patients (36%, P less than 0.01), as well as significantly higher levels of CIC. Acute exacerbations were also associated with significant increases in IgG antibody to Pseudomonas (P less than 0.005) but not in other antibodies. CIC did not correlate with Pseudomonas-specific IgG nor with any other specific antibody studied. A variety of age-related differences in specific antibody levels were seen. The episodic appearance of CIC is common in CF and is usually associated with exacerbation of lung disease.
- OSTI ID:
- 5549398
- Journal Information:
- J. Pediatr.; (United States), Vol. 99:2
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
ANTIGEN-ANTIBODY REACTIONS
RADIOIMMUNOASSAY
FIBROSIS
DIAGNOSIS
IODINE 125
DIAGNOSTIC USES
RESPIRATORY SYSTEM DISEASES
ANTIBODIES
ASPERGILLUS
CANDIDA
IMMUNOGLOBULINS
LUNGS
PATHOLOGY
PATIENTS
PSEUDOMONAS
STAPHYLOCOCCUS
BACTERIA
BETA DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
FUNGI
GLOBULINS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MICROORGANISMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PLANTS
PROTEINS
RADIOASSAY
RADIOISOTOPES
RESPIRATORY SYSTEM
TRACER TECHNIQUES
USES
YEASTS
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550201 - Biochemistry- Tracer Techniques
550901 - Pathology- Tracer Techniques