Formation of directly mutagenic alpha-hydroxy-N-nitrosopiperidine phosphate ester by near-ultraviolet irradiation of N-nitrosopiperidine in phosphate buffer

Journal Article · Tue Aug 15 00:00:00 EDT 1989 · Biochemical and Biophysical Research Communications; (USA)

DOI:https://doi.org/10.1016/0006-291X(89)90792-4· OSTI ID:5543538

Arimoto, S; Shimada, H; Ukawa, S; Mochizuki, M; Hayatsu, H ^[1]

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1. Okayama Univ. (Japan)

Previously we found that direct-acting mutagens can be formed from N-nitrosodialkylamines on exposure to near-ultraviolet light in the presence of phosphates. We have now isolated the mutagenic photoproduct formed from N-nitrosopiperidine and inorganic phosphate and identified its structure as the phosphate ester of alpha-hydroxy-N-nitrosopiperidine. This reaction represents a new, non-enzymatic activation of promutagenic N-nitrosodialkylamines.

• OSTI ID: 5543538
• Journal Information: Biochemical and Biophysical Research Communications; (USA), Vol. 162:3; ISSN 0006-291X
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
NITROSO COMPOUNDS
CHEMICAL RADIATION EFFECTS
BUFFERS
IN VITRO
MUTAGENS
NEAR ULTRAVIOLET RADIATION
PHOSPHATES
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RADIATIONS
ULTRAVIOLET RADIATION
560120* - Radiation Effects on Biochemicals
Cells
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