Randomized comparison of misonidazole sensitized radiotherapy plus BCNU and radiotherapy plus BCNU for treatment of malignant glioma after surgery; preliminary results of an RTOG study
- Univ. of Pennsylvania School of Medicine, Philadelphia
A randomized prospective was performed to evaluate misonidazole radiosensitized radiation therapy in the treatment of malignant glioma. The control arm, Group A, consisted of conventional radiation therapy (6000 cGy/6 to 7 weeks) to the whole brain plus BCNU (80 mg/m/sup 3/ on day 3, 4, 5, and then repeated q 8 weeks for 2 years). The BCNU schedule was identical in both arms. In the experimental arm, Group B, misonidazole 2.5 gm/m/sup 2/ was given once a week for six weeks, to a total dose of 15 gm/m/sup 2/. It was given orally four hours prior to 400 cGy on Mondays. On Tuesdays, Thursdays and Fridays, 150 cGy was delivered to a total of 5100 cGy/6 weeks. An additional 900 cGy/5F/1 week was given without misonidazole. Patients were stratified according to the prognostic factors of age, performance status, and histology. There is no significant difference in the survival of the two groups. The median survival for Group A was 12.6, and for Group B, 10.7 months. Misonidazole toxicity included an 11% peripheral neuropathy and a 3% central nervous system toxicity. BCNU toxicity included severe hematologic toxicity in 25%, including one death, and significant pulmonary toxicity in 6 out of 55 patients who received a minimum total dose of 960 mg/m/sup 2/ of BCNU.
- OSTI ID:
- 5533778
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 9:8; Conference: 18. annual ASCO meeting, St. Louis, MO, USA, 25 Apr 1982
- Country of Publication:
- United States
- Language:
- English
Similar Records
Value of adjuvant misonidazole in the definitive irradiation of advanced head and neck squamous cancer: an RTOG pilot study (number78-02)
Value of adjuvant misonidazole in the definitive irradiation of advanced head and neck squamous cancer: an RTOG pilot study (78-02)
Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
GLIOMAS
CHEMOTHERAPY
RADIOTHERAPY
MISONIDAZOLE
RADIOSENSITIVITY EFFECTS
TOXICITY
NITRO COMPOUNDS
BRAIN
IONIZING RADIATIONS
PATIENTS
SURVIVAL TIME
ANTINEOPLASTIC DRUGS
AZOLES
BODY
CENTRAL NERVOUS SYSTEM
DISEASES
DRUGS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
MEDICINE
NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIATIONS
RADIOLOGY
RADIOSENSITIZERS
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)
560151 - Radiation Effects on Animals- Man
550600 - Medicine