Action spectrum for phototherapy of psoriasis
Using a monochromator the action spectrum for ultraviolet phototherapy of psoriasis was determined for radiation between 254 and 313 nm and compared to the action spectrum for erythema of uninvolved adjacent skin. Daily exposures of different doses of 254, 280, 290, 296, 300, 304 and 313 nm radiation were observed. Wavelengths of 254, 280, 290 nm were erythemogenic but not therapeutic even at 10 to 50 times the minimal erythema dose. At the other wavelengths studied, the 2 action spectra were similar. In general, fixed daily doses cleared at lower cumulative dose than did incrementally increased daily doses. The small number of suberythemogenic exposure doses required suggests that monochromatic radiation may have advantages over broadband sources.
- OSTI ID:
- 5503925
- Journal Information:
- J. Invest. Dermatol.; (United States), Vol. 76:5
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
PSORIASIS
RADIOTHERAPY
SKIN
CUMULATIVE RADIATION EFFECTS
DOSE-RESPONSE RELATIONSHIPS
ERYTHEMA
FRACTIONATED IRRADIATION
MONOCHROMATIC RADIATION
RADIATION DOSES
SPECTRAL FUNCTIONS
ULTRAVIOLET RADIATION
BODY
DISEASES
DOSES
ELECTROMAGNETIC RADIATION
FUNCTIONS
IRRADIATION
MEDICINE
NUCLEAR MEDICINE
ORGANS
RADIATIONS
RADIOLOGY
SKIN DISEASES
SYMPTOMS
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)
560151 - Radiation Effects on Animals- Man