Recurrent tumors of the head and neck, pelvis, and chest wall: Treatment with hyperthermia and brachytherapy

Journal Article · Fri Sep 01 00:00:00 EDT 1989 · Radiology; (USA)

DOI:https://doi.org/10.1148/radiology.172.3.2772199· OSTI ID:5479712

Rafla, S; Parikh, K; Tchelebi, M; Youssef, E; Selim, H; Bishay, S ^[1]

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1. Methodist Hospital, Brooklyn, NY (USA)

Cancer that recurs after surgery and radiation therapy remains a major problem. The claimed effectiveness of thermobrachytherapy in patients with this problem prompted the present study. Forty-six lesions (20 head and neck, 18 pelvic, seven chest wall, and one limb sarcoma) in 38 patients were treated with interstitial hyperthermia that sandwiched the use of Ir-192 with the aim of delivering 2,000-6,000 cGy, depending on prior dose and tissue tolerance. Complete regression occurred in 19 (54%) of 35 evaluable cases. More than 58,000 measured temperature points were analyzed to develop a representative quantitative measure, the modal thermal dose, that represented the temperature reported most often during heating sessions. The pattern was plotted in each case. No significant relation was found between heating patterns and tumor response. Of all the prognostic factors studied, the radiation dose was the most significant, with a complete response rate being 78% when the total radiation dose exceeded 6,000 cGy, compared with 8% when the dose was lower than 5,000 cGy (P less than .005). The tumor volume also was important, with smaller lesions responding much better than larger ones (P = .1).

• OSTI ID: 5479712
• Journal Information: Radiology; (USA), Vol. 172:3; ISSN 0033-8419
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CHEST
NEOPLASMS
HEAD
HYPERTHERMIA
RADIOSENSITIVITY EFFECTS
NECK
RADIOTHERAPY
PELVIS
IRIDIUM 192
RADIATION DOSES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BODY AREAS
BODY TEMPERATURE
DAYS LIVING RADIOISOTOPES
DISEASES
DOSES
ELECTRON CAPTURE RADIOISOTOPES
HEAVY NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRIDIUM ISOTOPES
ISOMERIC TRANSITION
ISOTOPES
MEDICINE
NUCLEAR MEDICINE
NUCLEI
RADIOISOTOPES
RADIOLOGY
THERAPY
550603* - Medicine- External Radiation in Therapy- (1980-)