Fused liposome and acid induced method for liposome fusion

Patent · Tue Dec 06 00:00:00 EST 1988

OSTI ID:5471809

Huang, L; Connor, J

This patent describes a method of fusing liposomes. It comprises: preparing a suspension of liposomes containing at least one lipid which has a tendency to form the inverted hexagonal phase and at least 20 mol percent of palmitoylhomocysteine; and in the absence of externally added divalent cations, proteins or other macromolecules, acidifying the liposome suspension to reduce the pH of the liposomes to below pH 7, such that at least about 20% of the liposomes fuse to one another.

• Assignee: University of TN Research Corp., Knoxville, TN
• Patent Number(s): US 4789633
• Application Number: PPN: US 6602177A
• OSTI ID: 5471809
• Resource Relation: Patent File Date: 19 Apr 1984
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
LIPIDS
SOLVENT PROPERTIES
LIPOSOMES
HYBRIDIZATION
ACIDIZATION
CHEMICAL COMPOSITION
CHEMICAL REACTIONS
HOMOCYSTEINE
MIXTURES
PH VALUE
SOLVENT EXTRACTION
AMINO ACIDS
CARBOXYLIC ACIDS
CELL CONSTITUENTS
DISPERSIONS
EXTRACTION
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANOIDS
SEPARATION PROCESSES
550300* - Cytology