99mTc-DTPA and /sup 131/I-hippuran findings in liver transplant recipients treated with cyclosporin A
The effects of cyclosporin A (CyA), an immunosuppressive agent that is potentially nephrotoxic, on the kidneys of 9 liver transplant recipients were studied with serial 99mTc-DTPA and 131I-hippuran scans. In addition, renal function was determined by measuring serum creatinine levels during the second postoperative week in the 9 unselected CyA-treated patients and, retrospectively, in a control group of 29 liver transplant recipients who had not been treated with CyA and who were selected because they had survived for at least 3 months postoperatively. The early postoperative creatinine level was significantly greater in the CyA group. Eight of the 9 CyA patients showed imaging abnormalities in all preoperative and postoperative studies. Five of the 8 patients showed a pattern similar to that of acute tubular necrosis (relatively preserved perfusion) in at least one study. Lowering the dosage of CyA permitted the continuation of therapy, and all 9 patients are alive after 8 to 14 months.
- Research Organization:
- University of Colorado Health Sciences Center, Denver
- OSTI ID:
- 5466371
- Journal Information:
- Radiology; (United States), Vol. 142:1
- Country of Publication:
- United States
- Language:
- English
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IMMUNOSUPPRESSIVE DRUGS
TOXICITY
KIDNEYS
RADIOISOTOPE SCANNING
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CREATININE
HIPPURAN
IODINE 131
ISOMERIC NUCLEI
PATIENTS
RENAL CLEARANCE
TECHNETIUM 99
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BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
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CONTRAST MEDIA
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DIGESTIVE SYSTEM
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GLANDS
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HOURS LIVING RADIOISOTOPES
IMIDAZOLES
IMINES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
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TECHNETIUM ISOTOPES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics