Experimental radioimmunotherapy of a xenografted human colonic tumor (GW-39) producing carcinoembryonic antigen

Journal Article · Sun Nov 01 00:00:00 EST 1981 · Cancer Res.; (United States)

OSTI ID:5456791

Goldenberg, D M; Gaffar, S A; Bennett, S J; Beach, J L

Experiments were undertaken to evaluate the antitumor effects of 131I-labeled goat antibody immunoglobulin G prepared against carcinoembryonic antigen in hamsters bearing the carcinoembryonic antigen-producing GW-39 human colonic carcinoma. At a single injection of 1 mCi 131I and higher, a marked growth inhibition of GW-39 tumors, as well as a considerable increase in the survival time of the tumor-bearing hamsters, could be achieved. At a dose of 1 mCi, the radioactive affinity-purified antibody appeared to be superior to radioactive normal goat immunoglobulin G in influencing tumor growth and survival time, but no significant difference could be seen at the higher dose of 2 mCi given. Radiobiological calculations indicated that the tumors received, at up to 20 days after therapy, 1325 rads for the specific antibody and only 411 rads for the normal immunoglobulin G preparation. These findings encourage the further evaluation of antibodies to tumor markers for isotopic cancer therapy.

• Research Organization: University of Kentucky College of Medicine, Lexington
• OSTI ID: 5456791
• Journal Information: Cancer Res.; (United States), Vol. 41:11 Pt 1
• Country of Publication: United States
• Language: English

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