Mononuclear cells in the corneal response to endotoxin
A severe keratitis can be produced after the direct injection of bacterial endotoxin, or lipopolysaccharide (LPS), in rabbits. Corneal inflammation can progress to scarring and vascularization within a 2 to 3 week period. Pretreatment with systemic adrenal corticosteroids (triamcinolone) prevents this response. Limbal cellular and vascular events were studied during the first 20 hr after injection of LPS in treated and nontreated rabbits. Perivascular limbal inflammatory cells were counted and limbal vascular permeability was assessed by extravasation of 131I-albumin and 125I-fibrinogen in the cornea. Corticosteroids decreased but did not prevent the early protein extravasation and profoundly altered the inflammatory cell population around blood vessels at the limbus. Mononuclear cells, particularly mononuclear phagocytes, were sharply reduced. It is proposed that these cell types play an important role in the perpetuation and amplification of the inflammatory response in this reaction.
- Research Organization:
- Department of Pathology, University of Calfornia Medical School, San Francisco
- OSTI ID:
- 5451603
- Journal Information:
- Invest. Ophthalmol. Visual Sci.; (United States), Vol. 22:4
- Country of Publication:
- United States
- Language:
- English
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CORNEA
INFECTIVITY
BIOCHEMISTRY
CORTICOSTEROIDS
ENDOTOXINS
ESCHERICHIA COLI
INFLAMMATION
IODINE 125
IODINE 131
LIPOPOLYSACCHARIDES
PERMEABILITY
RABBITS
ADRENAL HORMONES
ANIMALS
ANTIGENS
BACTERIA
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BODY AREAS
CARBOHYDRATES
CHEMISTRY
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
EYES
FACE
HEAD
HORMONES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
KETONES
LIPIDS
MAMMALS
MATERIALS
MICROORGANISMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
POLYSACCHARIDES
PREGNANES
RADIOISOTOPES
SACCHARIDES
SENSE ORGANS
STEROID HORMONES
STEROIDS
SYMPTOMS
TOXIC MATERIALS
TOXINS
VERTEBRATES
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