The effect of iron on the biodistribution of bone scanning agents in humans
Nine patients with chronic iron overload, resulting from either repeated transfusions or hemochromatosis, had bone scans that were characterized by a reduction of bony uptake, marked increase in renal activity, and a significant increase in soft-tissue accumulation of 99mTc-labeled bone-seeking agents. These findings were supported by semiquantitative computer analysis. The probable mechanisms of altered biodistribution and the possible role of serum ferritin are discussed. The importance of realizing the effect of excess iron on skeletal scintigraphy is further emphasized by the results of bone scanning in another patient in whom acute iron overload following infusion of iron-dextran resulted in excessive blood pool labeling.
- OSTI ID:
- 5427885
- Journal Information:
- Radiology; (United States), Vol. 140:1
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
BONE SEEKERS
TISSUE DISTRIBUTION
IRON
BIOLOGICAL EFFECTS
TECHNETIUM 99
DIAGNOSTIC USES
BLOOD
BUILDUP
COMPARATIVE EVALUATIONS
ISOMERIC NUCLEI
PATIENTS
QUANTITATIVE CHEMICAL ANALYSIS
SCINTISCANNING
SKELETON
TRANSFUSIONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CHEMICAL ANALYSIS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
ELEMENTS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MATERIALS
METALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
TECHNETIUM ISOTOPES
THERAPY
TRANSITION ELEMENTS
USES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550201 - Biochemistry- Tracer Techniques
551001 - Physiological Systems- Tracer Techniques