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Title: Creatine kinase MB isoenzyme in dermatomyositis: a noncardiac source

Abstract

Three patients with polymyositis had elevated serum levels of creatine kinase MB isoenzyme. The presence of this isoenzyme is used extensively to diagnose myocardial infarction, but the isoenzyme is also found in sera of patients with primary muscular and neuromuscular disorders. Researchers studied cardiac function in two of our patients with electrocardiograms, technetium stannous pyrophosphate scanning, and technetium 99m-labeled erythrocyte gated blood pool imaging and in the third patient by postmortem examination. There was no evidence of myocardial involvement to account for the high serum levels of isoenzyme. Creatine kinase MB in the sera of patients with polymyositis does not necessarily indicate myocardial necrosis.

Authors:
; ;
Publication Date:
OSTI Identifier:
5394263
Resource Type:
Journal Article
Journal Name:
Ann. Intern. Med.; (United States)
Additional Journal Information:
Journal Volume: 94:3
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; BLOOD SERUM; QUANTITATIVE CHEMICAL ANALYSIS; ISOENZYMES; ENZYME ACTIVITY; MYOCARDIAL INFARCTION; DIAGNOSIS; COMPARATIVE EVALUATIONS; DIAGNOSTIC USES; ERYTHROCYTES; HEART; LABELLED COMPOUNDS; MUSCLES; NECROSIS; PATHOLOGY; PATIENTS; PHOSPHOTRANSFERASES; SCINTISCANNING; TECHNETIUM 99; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; CHEMICAL ANALYSIS; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; DISEASES; ENZYMES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANS; PATHOLOGICAL CHANGES; PHOSPHORUS-GROUP TRANSFERASES; RADIOISOTOPE SCANNING; RADIOISOTOPES; TECHNETIUM ISOTOPES; TRANSFERASES; USES; YEARS LIVING RADIOISOTOPES; 550201* - Biochemistry- Tracer Techniques; 550901 - Pathology- Tracer Techniques

Citation Formats

Larca, L J, Coppola, J T, and Honig, S. Creatine kinase MB isoenzyme in dermatomyositis: a noncardiac source. United States: N. p., 1981. Web. doi:10.7326/0003-4819-94-3-341.
Larca, L J, Coppola, J T, & Honig, S. Creatine kinase MB isoenzyme in dermatomyositis: a noncardiac source. United States. https://doi.org/10.7326/0003-4819-94-3-341
Larca, L J, Coppola, J T, and Honig, S. 1981. "Creatine kinase MB isoenzyme in dermatomyositis: a noncardiac source". United States. https://doi.org/10.7326/0003-4819-94-3-341.
@article{osti_5394263,
title = {Creatine kinase MB isoenzyme in dermatomyositis: a noncardiac source},
author = {Larca, L J and Coppola, J T and Honig, S},
abstractNote = {Three patients with polymyositis had elevated serum levels of creatine kinase MB isoenzyme. The presence of this isoenzyme is used extensively to diagnose myocardial infarction, but the isoenzyme is also found in sera of patients with primary muscular and neuromuscular disorders. Researchers studied cardiac function in two of our patients with electrocardiograms, technetium stannous pyrophosphate scanning, and technetium 99m-labeled erythrocyte gated blood pool imaging and in the third patient by postmortem examination. There was no evidence of myocardial involvement to account for the high serum levels of isoenzyme. Creatine kinase MB in the sera of patients with polymyositis does not necessarily indicate myocardial necrosis.},
doi = {10.7326/0003-4819-94-3-341},
url = {https://www.osti.gov/biblio/5394263}, journal = {Ann. Intern. Med.; (United States)},
number = ,
volume = 94:3,
place = {United States},
year = {Sun Mar 01 00:00:00 EST 1981},
month = {Sun Mar 01 00:00:00 EST 1981}
}