Sensitivity of scintigraphy for detection of pulmonary capillary albumin leak in canine oleic acid ARDS

Journal Article · Wed Jul 01 00:00:00 EDT 1981 · J. Trauma; (United States)

DOI:https://doi.org/10.1097/00005373-198107000-00003· OSTI ID:5392890

Sugerman, H J; Strash, A M; Hirsch, J I; Glauser, F L; Shirazi, K K; Sharp, D E; Greenfield, L J

Computerized gamma scintigraphy was shown in this study to be a sensitive technique for the detection and kinetic analysis of a pulmonary capillary protein leak. A rising lung:heart radioactivity of slope of injury was found at each dose of intravenous oleic acid in dogs from 0.01 to 0.20 ml/kg (p less than 0.01). This slope of injury was proportional to the dose of oleic acid (r . +0.97; p less than 0.004) and was more sensitive than changes in arterial oxygen tension, standard chest radiography, bloodless wet:dry lung weight, or alveolar epithelial membrane permeability. Only standard light microscopy and right lymphatic duct flow were able to document the leakage of protein detected by gamma scintigraphy at 0.01 ml/kg oleic acid.

• OSTI ID: 5392890
• Journal Information: J. Trauma; (United States), Vol. 21:7
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
HEART
SCINTISCANNING
LUNGS
TECHNETIUM 99
DIAGNOSTIC USES
VASCULAR DISEASES
DIAGNOSIS
ALBUMINS
ALGINIC ACID
BIOLOGICAL HALF-LIFE
CAPILLARIES
CELL MEMBRANES
COMPUTERS
DOGS
GAMMA RADIATION
IMAGES
OXYGEN
PERMEABILITY
RADIATION DOSES
RADIONUCLIDE KINETICS
RESPIRATION
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
CARBOHYDRATES
CARDIOVASCULAR SYSTEM
CELL CONSTITUENTS
COLLOIDS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
DISPERSIONS
DOSES
ELECTROMAGNETIC RADIATION
ELEMENTS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MEMBRANES
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
POLYSACCHARIDES
PROTEINS
RADIATIONS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
SACCHARIDES
TECHNETIUM ISOTOPES
USES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
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