Total body irradiation in chronic myeloid leukemia

Journal Article · Fri Apr 01 00:00:00 EST 1983 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(83)90067-6· OSTI ID:5391593

Advani, S H; Dinshaw, K A; Nair, C N; Ramakrishnan, G

Total body irradiation (TBI), given as 10 rad daily for five days a week for a total dose of 150 rad has been used in an attempt to control the chronic phase of chronic myeloid leukemia (CML). Thirteen patients with CML received fractionated TBI leading to rapid and good control of WBC count without any adverse reaction. The chronic phase of CML could also be controlled with TBI, even in three patients who were resistant to busulfan. Following TBI, WBC count remained under control for a period of 32 weeks as compared to 40 weeks following vusulfan alone. Repeat TBI was also well tolerated with good response. It appears that TBI is an effective and safe therapy for controlling the chronic phase of CML.

• Research Organization: Tata Memorial Hospital, Bombay, India
• OSTI ID: 5391593
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 9:4
• Country of Publication: United States
• Language: English

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