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Title: Radiation therapy in and about the retina, optic nerve, and anterior visual pathway. Psychophysical assessment

Visual changes may develop in patients receiving radiation therapy for malignant neoplasms in and about the optic nerve and anterior visual pathway. Cases have been studied using a series of psychophysical tests, including kinetic perimetry, increment threshold determinations, Flashing Repeat Static Test, and sustained- and transient-like functions. A characteristic time-dependent reduction in sensitivity has been identified in these patients. This finding, in addition to the presence of nerve fiber bundle defects, appears to place the pathologic changes in the axon of the ganglion cell posterior to the lamina cribrosa. Any change in the sustained- and transient-like functions, the organization of which appears to be in the neural retina, was seen only if a concomitant radiation retinopathy was identified.
Authors:
; ;
Publication Date:
OSTI Identifier:
5390851
Resource Type:
Journal Article
Resource Relation:
Journal Name: Arch. Ophthalmol. (Chicago); (United States); Journal Volume: 99:4
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CARCINOMAS; BIOLOGICAL RADIATION EFFECTS; VISION; PATHOLOGY; PATIENTS; RADIONUCLIDE KINETICS; RADIOSENSITIVITY; RADIOTHERAPY; RETINA; SIDE EFFECTS; TIME DEPENDENCE; BIOLOGICAL EFFECTS; BODY; BODY AREAS; DISEASES; EYES; FACE; HEAD; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; ORGANS; RADIATION EFFECTS; RADIOLOGY; SENSE ORGANS; THERAPY 550603* -- Medicine-- External Radiation in Therapy-- (1980-); 560151 -- Radiation Effects on Animals-- Man