Internal irradiation for cystic craniopharyngioma
The authors report the results of internal irradiation with labeled chromic phosphate (32P) and gold-198 (198Au) colloid in eight cases of cystic craniopharyngiomas. They used a newly developed dosimetric formula, by which the radiation dose at the cyst wall and at any point far from the radioactive source can be calculated. Ten courses of irradiation in eight patients were carried out by injection of either 32P or 198Au colloid into the cyst through an Ommaya drainage system that had been placed at craniotomy. Follow-up studies ranging from 13 to 156 months revealed that all cysts were effectively treated, with elimination of fluid or collapse of the cyst. This was confirmed by Conray cystography and/or computerized tomography. Not only the dose delivered to the wall but also the thickness of the cyst wall and the location of the cyst are important factors in planning internal irradiation. A safe and adequate dose to the cyst wall could range between 9000 to 30,000 rads for craniopharyngioma. This treatment is suitable for large cysts that are thought to be difficult to remove radically, recurrent cysts resistant to previous treatment, or multiple cysts. Internal irradiation may also be applicable in other cystic intracranial tumors if dosimetry is calculated accurately.
- Research Organization:
- Department of Neurosurgery, Nagoya University School of Medicine, Japan
- OSTI ID:
- 5390654
- Journal Information:
- J. Neurosurg.; (United States), Vol. 55:6
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANGIOMAS
BIOLOGICAL RADIATION EFFECTS
GOLD 198
ISOTOPE APPLICATIONS
PHOSPHORUS 32
HEAD
INTERNAL IRRADIATION
PATIENTS
RADIATION DOSES
RADIOCOLLOIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
BODY AREAS
COLLOIDS
DAYS LIVING RADIOISOTOPES
DISEASES
DISPERSIONS
DOSES
GOLD ISOTOPES
HEAVY NUCLEI
IRRADIATION
ISOTOPES
LIGHT NUCLEI
NEOPLASMS
NUCLEI
ODD-ODD NUCLEI
PHOSPHORUS ISOTOPES
RADIATION EFFECTS
RADIOISOTOPES
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)
560171 - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987)
560151 - Radiation Effects on Animals- Man