(Non-invasive evaluation of the cardiac autonomic nervous system by PET)

Technical Report · Tue Jan 01 00:00:00 EST 1991

OSTI ID:5381369

Our research efforts in the first funding year concentrated on animal and clinical studies validating {sup 11}C-hydroxyephedrine as a marker for norepinephrine uptake and storage in presynaptic sympathetic nerve terminals. In addition to kinetic studies in animals, the first clinical studies have been performed. {sup 11}C-hydroxyephedrine provides excellent image quality in the human heart with high myocardium to blood ratios. A canine model with transient intracoronary occlusion of the left anterior descending aorta was used to show decreased retention of tracer with ischemia. Clinical studies of patients with acute myocardial infarction showed an area of decreased retention of tracer exceeding the infarct territory as defined by {sup 82}Rb blood flow imaging. We are also developing tracers for the parasympathetic nervous system. It appears that methyl-TRB is a specific tracer for this system. Studies of {sup 11}C- or {sup 18}F-benzovesamicol as a potential tracer for parasympathetic presynaptic nerve terminals are under way. (MHB)

• Research Organization: Michigan Univ., Ann Arbor, MI (United States). Div. of Nuclear Medicine
• Sponsoring Organization: USDOE; USDOE, Washington, DC (United States)
• DOE Contract Number: FG02-90ER61091
• OSTI ID: 5381369
• Report Number(s): DOE/ER/61091-1; ON: DE91018476
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
CARDIOVASCULAR DISEASES
DIAGNOSIS
HEART
POSITRON COMPUTED TOMOGRAPHY
RADIOPHARMACEUTICALS
TRACER TECHNIQUES
AUTONOMIC NERVOUS SYSTEM
BIOLOGICAL MODELS
BLOOD FLOW
CARBON 11
EPHEDRINE
FLUORINE 18
HISTOLOGY
LABELLING
MYOCARDIUM
PROGRESS REPORT
RADIONUCLIDE KINETICS
RECEPTORS
RUBIDIUM 82
SCINTISCANNING
TISSUE DISTRIBUTION
ALKALI METAL ISOTOPES
ALKALOIDS
AMINES
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBON ISOTOPES
CARDIOVASCULAR AGENTS
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
DISTRIBUTION
DOCUMENT TYPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
FLUORINE ISOTOPES
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MEMBRANE PROTEINS
MINUTES LIVING RADIOISOTOPES
MUSCLES
NANOSEC LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RUBIDIUM ISOTOPES
SYMPATHOMIMETICS
TOMOGRAPHY
VASOCONSTRICTORS
550601* - Medicine- Unsealed Radionuclides in Diagnostics
551000 - Physiological Systems