Hepatocellular carcinoma: Pilot trial of treatment with Y-90 microspheres

Journal Article · Fri Sep 01 00:00:00 EDT 1989 · Radiology; (USA)

DOI:https://doi.org/10.1148/radiology.172.3.2549567· OSTI ID:5359481

Houle, S; Yip, T K; Shepherd, F A; Rotstein, L E; Sniderman, K W; Theis, E; Cawthorn, R H; Richmond-Cox, K ^[1]

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1. Toronto General Hospital, Ontario (Canada)

The potential use of yttrium-90 glass microspheres in the treatment of hepatocellular carcinoma was assessed in a pilot study of seven patients. The Y-90 microspheres were injected via a hepatic artery catheter. In this group of patients, no toxicity was observed for absorbed doses of between 5,000 and 10,000 cGy to the liver and up to 32,000 cGy to the tumor itself. Tumor response was seen only at the higher absorbed doses. The new Y-90 glass microspheres can safely deliver large doses of internal radiation to hepatic tumors as long as extrahepatic shunting can be excluded. Extrahepatic shunting will be the main limitation to this form of radiation therapy.

• OSTI ID: 5359481
• Journal Information: Radiology; (USA), Vol. 172:3; ISSN 0033-8419
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOMAS
RADIOTHERAPY
LIVER
DOSE-RESPONSE RELATIONSHIPS
MICROSPHERES
PATIENTS
RADIATION DOSES
YTTRIUM 90
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISEASES
DOSES
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIOISOTOPES
RADIOLOGY
THERAPY
YTTRIUM ISOTOPES
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)