Atropine, diazepam, and physostigmine: Thermoregulatory effects in the heat-stressed rat
- Army Research Institute of Environmental Medicine, Natick, MA (USA)
The authors have previously reported that administration of atropine (A) to unrestrained, sedentary, heat-stressed rats resulted in a dose dependent increase in heating rate. Additionally, we have demonstrated that the decrements in treadmill endurance and increments in heating rate of physostigmine (PH)-treated running rats can both be restored to control levels by pretreating the animals with A and diazepam (D). Our objective in the present work was to determine if the administration of D+PH to A-treated unrestrained, sedentary, heat-stressed rats could improve their thermal tolerance. The following drugs were administered singly via lateral tail vein: vehicle-control (C), A (200 ug/kg), D (500 ug/kg), and PH (200 ug/kg). After drug administration, the rats were heat-stressed until a core temperature of 42.6{degree}C was attained when they were removed to a 26{degree}C chamber. The heating rates ({degree}C/min) and tolerance times (min) of the respective groups were: C- 0.02, 235; A- 0.08, 58; A+D- 0.06, 94; and A+D+PH- 0.04, 143. Administration of D with A significantly decreased heating rate, and D+PH more than doubled the thermal tolerance of A-treated rats. Thus, the combination of A+D+PH not only restores PH- induced performance and thermoregulatory decrements of rats exercised in a moderate environment, but also reduces A- induced heat intolerance.
- OSTI ID:
- 5349463
- Journal Information:
- Life Sciences; (USA), Vol. 44:25; ISSN 0024-3205
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ATROPINE
BIOLOGICAL EFFECTS
HEAT
PARASYMPATHOMIMETICS
BIOLOGICAL STRESS
RATS
TEMPERATURE EFFECTS
THERMOREGULATION
TOLERANCE
ALKALOIDS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
CONTROL
DRUGS
ENERGY
MAMMALS
ORGANIC COMPOUNDS
PARASYMPATHOLYTICS
RODENTS
TEMPERATURE CONTROL
VERTEBRATES
560200* - Thermal Effects