Antibody production in rats after long-term exposure to formaldehyde
- Karolinska Institutet (Sweden)
Sprague-Dawley rats were vaccinated with pneumococcal polysaccharide antigens and tetanus toxoid to evaluate the immunologic effects of long-term formaldehyde exposure. The antibody response to vaccination was measured 3 to 4 weeks later by enzyme-linked immunosorbent assay. An IgG response to pneumococcal polysaccharides and to tetanus toxoid was found in both the formaldehyde-exposed group and a control group of rats not exposed to formaldehyde. The IgM response to tetanus toxoid was significant in both groups but neither group showed a significant IgM response to pneumococcal polysaccharides. There were thus no signs of impaired B-cell function in rats exposed to a high concentration (12.6 ppm) of formaldehyde for nearly 2 years.
- OSTI ID:
- 5346203
- Journal Information:
- Toxicology and Applied Pharmacology; (USA), Vol. 100:2; ISSN 0041-008X
- Country of Publication:
- United States
- Language:
- English
Similar Records
Characterization of a human antigen specific helper factor
Binding of Klebsiella K/sub 2/ LPS to specific antibody and cross-reactivity with pneumococcal group 19 polysaccharides (PS)
Related Subjects
FORMALDEHYDE
BIOLOGICAL EFFECTS
LYMPHOCYTES
BIOLOGICAL FUNCTIONS
ANTIBODY FORMATION
CHRONIC EXPOSURE
ENZYME IMMUNOASSAY
IMMUNE REACTIONS
PNEUMOCOCCUS
POLYSACCHARIDES
RATS
TOXINS
VACCINES
ALDEHYDES
ANIMAL CELLS
ANIMALS
ANTIGENS
BACTERIA
BIOASSAY
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOHYDRATES
CONNECTIVE TISSUE CELLS
FUNCTIONS
IMMUNOASSAY
LEUKOCYTES
MAMMALS
MATERIALS
MICROORGANISMS
ORGANIC COMPOUNDS
RODENTS
SACCHARIDES
SOMATIC CELLS
TOXIC MATERIALS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology