Inhibition of platelet function by contrast media: iopamidol and ioxaglate versus iothalamate: work in progress
The effects of an ionic contrast agent, meglumine iothalamate (Conray-60), and two newer low-osmolality radiographic contrast media, sodium meglumine ioxaglate (Hexabrix) and iopamidol (B-15,000), on platelet aggregation and secretion responses were studied. All three agents inhibited platelet responses during stimulation with adenosine diphosphate (ADP), epinephrine, and collagen. Platelet function was inhibited by iothalamate at concentrations of 11 mg iodine/ml and above, and by the newer agents at concentrations above 30 mg iodine/ml. Addition of exogenous calcium decreased the iothalamate-induced inhibition of aggregation but did not improve dense granule secretion. These studies indicate that the newer agents inhibit platelet function less than iothalamate does, and that chelation of Ca/sup 2 +/ may not be the major mechanism of platelet inhibition by contrast agents.
- Research Organization:
- Temple Univ. School of Medicine, Philadelphia, PA
- OSTI ID:
- 5321378
- Report Number(s):
- CONF-851152-; TRN: 85-022581
- Journal Information:
- Radiology; (United States), Vol. 156:2; Conference: 71. scientific assembly and annual meeting, Chicago, IL, USA, 17 Nov 1985
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
BLOOD PLATELETS
AGGLOMERATION
CONTRAST MEDIA
BIOLOGICAL EFFECTS
BIOMEDICAL RADIOGRAPHY
CALCIUM CHLORIDES
CARBON 14 COMPOUNDS
INHIBITION
IOGLYCAMIC ACID
IOPAMIDOL
ACETAMIDE
ALKALINE EARTH METAL COMPOUNDS
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BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CALCIUM COMPOUNDS
CALCIUM HALIDES
CARBOXYLIC ACIDS
CHLORIDES
CHLORINE COMPOUNDS
DIAGNOSTIC TECHNIQUES
ETHERS
HALIDES
HALOGEN COMPOUNDS
LABELLED COMPOUNDS
MATERIALS
MEDICINE
MONOCARBOXYLIC ACIDS
NUCLEAR MEDICINE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
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