FKHL15, a new human member of the forkhead gene family located on chromosome 9q22

Journal Article · Thu May 01 00:00:00 EDT 1997 · Genomics

DOI:https://doi.org/10.1006/geno.1997.4692· OSTI ID:530735

Chadwick, B P; Obermayr, F; Frischauf, A M ^[1]

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1. Imperial Cancer Research Fund, London (United Kingdom)

FKHL15 was isolated from a cDNA library enriched for transcripts from 9q22. Isolation and sequencing of a 3.5-kb cDNA clone identified a putative 376-amino-acid protein with greater than 80% homology over a 100-amino-acid stretch to the forkhead DNA-binding domain. The FKHL15 gene contains a region rich in alanine residues, frequently associated with transcriptional repression. The forkhead genes are believed to play important roles in development and differentiation in many different organisms and have also been implicated in the development of some tumors. The map position of FKHL15 on 9q22 places the gene within the candidate regions for the cancer predisposition syndrome multiple self-healing squamous epitheliomata and the degenerative neurological disorder hereditary sensory neuropathy type 1. This is a region frequently lost in squamous cell cancer. 47 refs., 5 figs.

• OSTI ID: 530735
• Journal Information: Genomics, Vol. 41, Issue 3; Other Information: PBD: 1 May 1997
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
HUMAN CHROMOSOME 9
GENETIC MAPPING
NEOPLASMS
ETIOLOGY
PATIENTS
HEREDITARY DISEASES
GENES
GENE REGULATION
STRUCTURE-ACTIVITY RELATIONSHIPS
DNA-CLONING
DNA SEQUENCING
TRANSCRIPTION
GENE MUTATIONS
DNA HYBRIDIZATION
POLYMERASE CHAIN REACTION
CONTIGS
BIOLOGICAL MARKERS
ALANINES
AMINO ACID SEQUENCE
TUMOR PROMOTERS