Effect of hepatoprotectors on lipid metabolism in hepatitis induced by carbon tetrachloride

Journal Article · Tue Sep 01 00:00:00 EDT 1987 · Bull. Exp. Biol. Med. (Engl. Transl.); (United States)

DOI:https://doi.org/10.1007/BF00842475· OSTI ID:5284144

Vengerovskii, A I; Chuchalin, V S; Paul's,; V, O; Saratikov, A S

The authors study the effect of the widely used hepatoprotective agents- the flavonoid silybinin and the phosphatidylcholine-containing substance essentiale - on the combination of disturbances of lipid metabolism present in severe toxic hepatitis induced by carbon tetrachloride in rats. It was found that CCl/sub 4/ caused a profound disturbance of lipid metabolism. The hepatoprotective effect of silybinin and essentiale is due to their antioxidant action and to normalization of function of the liver phospholipids.

• Research Organization: Tomsk Medical Institute (USSR)
• OSTI ID: 5284144
• Journal Information: Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Vol. 103:4; Other Information: Translated from Byulleten' Ehksperimental'noj Biologii Meditsiny; 103: No. 4, 430-432(Apr 1987)
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
ANTIOXIDANTS
BIOLOGICAL EFFECTS
CARBON TETRACHLORIDE
BIOCHEMISTRY
TOXICITY
LIPIDS
METABOLISM
RATS
HEPATITIS
ACID PHOSPHATASE
ENZYME ACTIVITY
FLAVENOIDS
INHIBITION
LIPASE
LIVER
OXIDATION
OXIDOREDUCTASES
PATHOGENESIS
THIN-LAYER CHROMATOGRAPHY
ANIMALS
BODY
CARBOXYLESTERASES
CHEMICAL REACTIONS
CHEMISTRY
CHLORINATED ALIPHATIC HYDROCARBONS
CHROMATOGRAPHY
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
ENZYMES
ESTERASES
GLANDS
HALOGENATED ALIPHATIC HYDROCARBONS
HYDROLASES
MAMMALS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PHOSPHATASES
RODENTS
SEPARATION PROCESSES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
550500 - Metabolism