Medical Research and Evaluation Facility (MREF) and studies supporting the Medical Chemical Defense Program on Task 89-01: Screening of candidate pretreatment and therapeutic compounds in in vivo models. Final report Jul 89-Sep 91
This task was a continuation of Task 86-29 initiated for Contract D. It provided in vivo screens for evaluating the efficacy of candidate pretreatment and treatment compounds submitted by the Drug Assessment Division of U.S. Army Medical Research of Chemical Defense against soman, tabun, and/or cyanide. A total of 578 compounds were received for testing and their maximum solubility in-vehicles comparable with in vivo testing in mice was determined. Range-finding and median lethal dose determinations following IM and/or oral administrations were conducted for 436 compounds submitted for nerve agent screening and range finding and median lethal dose determinations following IP administration were conducted for up to 142 compounds submitted for cyanide screening. Of 332 compounds evaluated, 154 passed the GD treatment efficacy evaluation, and 90 of 156 compounds submitted passed the GA treatment efficacy evaluation. For pretreatment studies against a GD challenge, 224 of 379 compounds submitted passed the IM efficacy evaluation and 96 of 143 compounds submitted passed the oral efficacy evaluation. Only 12 of 133 compounds evaluated as cyanide pretreatment compounds passed the efficacy evaluations. The mission of Task 89-01 was combined under Task 91-20 for the duration of Contract DAMD17-89-C-9050.
- Research Organization:
- Battelle Memorial Inst., Columbus, OH (United States)
- OSTI ID:
- 5272405
- Report Number(s):
- AD-A-247682/8/XAB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CHEMICAL WARFARE AGENTS
BIOLOGICAL EFFECTS
DRUGS
SCREENING
CHEMOTHERAPY
CONTRACTS
CYANIDES
DETOXIFICATION
EVALUATION
MANAGEMENT
MICE
RESEARCH PROGRAMS
SOLUBILITY
TOXICITY
VEHICLES
ANIMALS
MAMMALS
RODENTS
THERAPY
VERTEBRATES
WEAPONS
450600* - Military Technology
Weaponry
& National Defense- Chemical & Biological- (1990)