Cobalt contraction of vascular smooth muscle

Conference · Mon Mar 11 00:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5266375

Dominiczak, A; Clyde, E; Bohr, D ^[1]

---

1. Univ. of Michigan, Ann Arbor (United States)

Although it has been reported that cobalt causes contraction of vascular smooth muscle, the mechanism responsible for this contraction has not been defined. The authors studied these contractions in rat aortic rings. Concentration-response studies indicated that the threshold for contraction was 10{sup {minus}8}M, maximum contraction occurred at 3 {times} 10{sup 7}M and relaxation began at 10{sup {minus}6}M. No contraction occurred in a calcium-free physiological salt solution and the contraction was not inhibited by H-7, a protein kinase C inhibitor. The authors conclude the cobalt in low concentrations causes contraction by activating calcium channels and that in high concentrations it causes relaxation by inactivating these same channels.

• OSTI ID: 5266375
• Report Number(s): CONF-9104107-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:4; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
COBALT
BIOLOGICAL EFFECTS
MUSCLES
VASOCONSTRICTION
AORTA
DOSE-RESPONSE RELATIONSHIPS
ENZYME INHIBITORS
RATS
ANIMALS
ARTERIES
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
ELEMENTS
MAMMALS
METALS
ORGANS
RODENTS
TRANSITION ELEMENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology