The effect of vitamin B sub 12 on selenium metabolism in the rat

Conference · Mon Mar 11 00:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5265223

Chen, C L; Whanger, P D ^[1]

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1. Oregon State Univ., Corvallis (United States)

Since animal methylate selenium (Se) and vitamin B{sub 12} is involved in methylation reactions, weaning rats were fed diets with or without vitamin B{sub 12} to evaluate its effect on Se metabolism. Plasma vitamin B{sub 12} of vitamin B{sub 12} depleted rats were below detection while vitamin B{sub 12} levels in plasma of control rats ranged from 3-6 ng/ml after 4 weeks feeding. After {sup 75}Se-selenite injection, vitamin B{sub 12} depleted rats exhaled 16% of the dose and excreted 22-28% as trimethylselenonium in urine as compared to 45% and 45-54% respectively in control rats. Se methylation experiments with rat liver supernatants from vitamin B{sub 12} depleted rats volatilized only 45% as the control rat liver preparation. When rats were fed various levels of Se as selenite, blood and heart Se levels were higher in vitamin B{sub 12} supplemented rats, but lower in liver, kidney, spleen and testis than the deficient rats. This difference in liver between supplemented and deficient rats became greater with higher dietary levels of Se. It is concluded that vitamin B{sub 12} affects Se metabolism through the methylation of this element.

• OSTI ID: 5265223
• Report Number(s): CONF-9104107-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:4; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
SELENIUM
METABOLISM
VITAMIN B-12
BIOLOGICAL EFFECTS
LIVER
METHYLATION
RATS
SELENIUM 75
TISSUE DISTRIBUTION
TRACER TECHNIQUES
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CHEMICAL REACTIONS
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
GLANDS
HEMATINICS
HEMATOLOGIC AGENTS
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NUCLEI
ORGANS
RADIOISOTOPES
RODENTS
SELENIUM ISOTOPES
SEMIMETALS
VERTEBRATES
VITAMIN B GROUP
VITAMINS
560300* - Chemicals Metabolism & Toxicology