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Title: Electromagnetic field effects on cells of the immune system: The role of calcium signalling

During the past decade considerable evidence has accumulated demonstrating the exposures of cells of the immune system to relatively weak extremely-low-frequency (ELF) electromagnetic fields (< 300 Hz) can elicit cellular changes which might be relevant to in-vivo immune activity. However, knowledge about the underlying biological mechanisms by which weak fields induce cellular changes is still very limited. It is generally believed that the cell membrane and Ca{sup 2+} regulated activity is involved in bioactive ELF field-coupling to living systems. This article begins with a short review of the current state of knowledge concerning the effects of nonthermal levels of ELF electromagnetic fields on the biochemistry and activity of immune cells, and then closely examines new results which suggest a role for Ca{sup 2+} in the induction of these cellular field effects. Based on these findings it is proposed that membrane-mediated Ca{sup 2+} signalling processes are involved in the mediation of field effects on the immune system. 64 refs., 2 tabs.
Authors:
Publication Date:
OSTI Identifier:
5261345
Report Number(s):
LBL-31097; CONF-9104107--1
ON: DE92000852
DOE Contract Number:
AC03-76SF00098
Resource Type:
Conference
Resource Relation:
Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991
Research Org:
Lawrence Berkeley Lab., CA (United States)
Sponsoring Org:
DOE; USDOE, Washington, DC (United States)
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; BIOLOGICAL PATHWAYS; CALCIUM; MEMBRANE TRANSPORT; ELECTROMAGNETIC FIELDS; BIOLOGICAL EFFECTS; BIOLOGICAL MODELS; BIOPHYSICS; CALCIUM 45; CELL TRANSFORMATIONS; DNA REPLICATION; EPIDEMIOLOGY; LEUKOCYTES; MICROWAVE RADIATION; RADIOWAVE RADIATION; RECEPTORS; REVIEWS; TRACER TECHNIQUES; TRANSCRIPTION; ALKALINE EARTH ISOTOPES; ALKALINE EARTH METALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CALCIUM ISOTOPES; DAYS LIVING RADIOISOTOPES; DOCUMENT TYPES; ELECTROMAGNETIC RADIATION; ELEMENTS; EVEN-ODD NUCLEI; INTERMEDIATE MASS NUCLEI; ISOTOPE APPLICATIONS; ISOTOPES; MATERIALS; MEMBRANE PROTEINS; METALS; NUCLEI; NUCLEIC ACID REPLICATION; ORGANIC COMPOUNDS; PROTEINS; RADIATIONS; RADIOISOTOPES 560400* -- Other Environmental Pollutant Effects; 550300 -- Cytology; 551000 -- Physiological Systems