A broader perspective of sexual differentiation

Journal Article · Mon Mar 31 00:00:00 EST 1997 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/(SICI)1096-8628(19970331)69:3<229::AID-AJMG2>3.0.CO;2-G· OSTI ID:525997

Fiddler, M ^[1]; Pergament, E ^[2]

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1. DePaul Univ., Chicago, IL (United States)
2. Northwestern Univ. Medical School, Chicago, IL (United States)

Human sexual differentiation is customarily depicted as a series of embryonic events that lead to male and female gonadal development and differential hormone expression that have behavioral as well as biological outcomes. The salient components of these events are the differential expression of two hormones - testosterone and Muellerian inhibiting substance - and the SRY gene, regulating, in turn, the transcription of other genes and culminating in male differentiation. Sex determination, then, is generally described as initially proceeding down a path toward female development unless the bipotential, indifferent gonad is modified toward male development by genes on the Y chromosome. 28 refs.

• OSTI ID: 525997
• Journal Information: American Journal of Medical Genetics, Vol. 69, Issue 3; Other Information: PBD: 31 Mar 1997
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
HUMAN Y CHROMOSOME
GENETIC MAPPING
GENES
TRANSCRIPTION
GENE REGULATION
EMBRYOS
ONTOGENESIS
SEX
HUMAN CHROMOSOMES
CHROMOSOMAL ABERRATIONS
GONADS
GENETICS
PHENOTYPE
HORMONES
TESTOSTERONE