Dose-response model for teratological experiments involving quantal responses
Journal Article
·
· Biometrics; (United States)
This paper introduces a dose-response model for teratological quantal response data where the probability of response for an offspring from a female at a given dose varies with the litter size. The maximum likelihood estimators for the parameters of the model are given as the solution of a nonlinear iterative algorithm. Two methods of low-dose extrapolation are presented, one based on the litter size distribution and the other a conservative method. The resulting procedures are then applied to a teratological data set from the literature.
- Research Organization:
- California State Polytechnic Univ., Pomona
- OSTI ID:
- 5241605
- Journal Information:
- Biometrics; (United States), Vol. 1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DOSE-RESPONSE RELATIONSHIPS
MATHEMATICAL MODELS
TERATOGENS
BIOLOGICAL EFFECTS
ALGORITHMS
BIOLOGICAL MODELS
EXTRAPOLATION
LITTER SIZE
MATHEMATICS
PREGNANCY
PROBABILITY
PROGENY
MATHEMATICAL LOGIC
NUMERICAL SOLUTION
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
DOSE-RESPONSE RELATIONSHIPS
MATHEMATICAL MODELS
TERATOGENS
BIOLOGICAL EFFECTS
ALGORITHMS
BIOLOGICAL MODELS
EXTRAPOLATION
LITTER SIZE
MATHEMATICS
PREGNANCY
PROBABILITY
PROGENY
MATHEMATICAL LOGIC
NUMERICAL SOLUTION
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)