Metabolism of /sup 74/As-labeled trivalent and pentavalent inorganic arsenic in mice
Man is exposed to different forms of arsenic in the environment but differences in metabolism and toxicity are poorly understood. The differences in metabolism between pentavalent and trivalent inorganic arsenic in mice following single oral administration of /sup 74/As-labeled arsenate or arsenite (0.4 and 4 mg As/kg body wt) was studied. Valence state of the administered arsenic was strictly controlled, which has not always been the case in previous studies. In mice given the high dose, whole body retention was two to three times higher after exposure to As(III) compared to As(V). Retention was also dose dependent. Five weeks after administration, high dose/low dose retention ratios were 6 and 11 for As(V)and As(III). Differences found in most organs studied (blood, kidney, liver, bile, brain, skeleton, and skin) were most obvious in liver and bile with concentrations 2 to 10 times higher in the As(III) groups. Red cell/plasma ratios were 2 to 3 for As(III) and close to unity for As(V). It is suggested that the observed differences between As(V) and As(III) are due to differences in degree of methylation and subsequent elimination primarily via the kidneys.
- Research Organization:
- National Environment Protection Board, Stockholm, Sweden
- OSTI ID:
- 5128351
- Journal Information:
- Environ. Res.; (United States), Vol. 21:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ARSENIC
METABOLISM
ARSENIC 74
BILE
BLOOD
BRAIN
COMPARATIVE EVALUATIONS
EXCRETION
KIDNEYS
LABELLED COMPOUNDS
LIVER
METHYLATION
MICE
RESPONSE MODIFYING FACTORS
RETENTION
SKELETON
SKIN
TISSUE DISTRIBUTION
TRACER TECHNIQUES
VALENCE
ANIMALS
ARSENIC ISOTOPES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CENTRAL NERVOUS SYSTEM
CHEMICAL REACTIONS
CLEARANCE
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
GLANDS
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIOISOTOPES
RODENTS
SECONDS LIVING RADIOISOTOPES
SEMIMETALS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)