Possible effects of fluorides on the thyroid

Journal Article · Thu Apr 01 04:00:00 EST 1976 · Fluoride; (United States)

OSTI ID:5117956

McLaren, J R

A review of the literature on the relationship of fluorides and the thyroid gland reveals that the fluoride concentration within the thyroid gland on a wet basis is frequently at levels approximating, or above, those of blood and also, frequently, above those of other tissues including the kidneys. According to some investigators the fluoride concentration in the thyroid decreases at a slower rate than in other organs once animals are removed from fluoride intake. Fluoride appears to be actively concentrated by some of the thyroid cells and metabolized into such a form that it is not lost as readily as it is from other tissues when blood levels decrease. Fluorides at sufficient concentration produce profound morphological changes in the thyroid. The lower level of fluoride intake at which this may occur is open to discussion. Functional changes, however, may be seen frequently at daily intakes of 5 mg. Changes in activity of adenyl-cyclase concentrations are frequently encountered in thyroid glands at current levels of fluoride pollution. To date, analytical methods have not permitted these changes to be shown in vivo.

• OSTI ID: 5117956
• Journal Information: Fluoride; (United States), Journal Name: Fluoride; (United States) Vol. 9:2; ISSN FLUOA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CYCLASES
DISTRIBUTION
ENDOCRINE GLANDS
ENZYME ACTIVITY
ENZYMES
FLUORIDES
FLUORINE COMPOUNDS
GLANDS
HALIDES
HALOGEN COMPOUNDS
LYASES
MATERIALS
METABOLISM
MORPHOLOGICAL CHANGES
ORGANS
THYROID
TISSUE DISTRIBUTION