Lymphatic and hematopoietic tissue cancer in a chemical manufacturing environment

Journal Article · Sun Jan 01 00:00:00 EST 1989 · American Journal of Industrial Medicine; (USA)

DOI:https://doi.org/10.1002/ajim.4700160603· OSTI ID:5043335

Ott, M G; Teta, M J; Greenberg, H L ^[1]

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1. Arthur D. Little, Inc., Cambridge, MA (USA)

Nested case-control studies of non-Hodgkin's lymphoma (52 cases), multiple myeloma (20 cases), nonlymphocytic leukemia (39 cases), and lymphocytic leukemia (18 cases) were conducted within a cohort of employed men from two chemical manufacturing facilities and a research and development center. Exposure odds ratios were examined in relation to 111 work areas, 21 specific chemicals, and 52 chemical activity groups. Associations were observed for a maintenance and construction subgroup (non-Hodgkin's lymphoma) and a chlorohydrin production unit (nonlymphocytic leukemia). The odds ratio for the association of foremen and others with non-Hodgkin's lymphoma was 3.2 (CI95 = 1.47-7.2) based on 11 cases. A duration-response trend was observed for the chlorohydrin unit with three of four cases assigned 5+ years to that unit. An association between non-Hodgkin's lymphoma and assignment to strong acid alcohol production units (OR = 8.3; CI95 = 2.3-30.7) was not supported by a duration-response trend. Two highly correlated chemical groups, antioxidants (five cases) and nitriles (four cases), were over-represented among multiple myeloma cases. A duration effect was observed. However, examination of work histories did not reveal common jobs or departments among these cases.

• OSTI ID: 5043335
• Journal Information: American Journal of Industrial Medicine; (USA), Vol. 16:6; ISSN 0271-3586
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTIOXIDANTS
CARCINOGENESIS
CHEMICAL INDUSTRY
HEALTH HAZARDS
LEUKEMIA
EPIDEMIOLOGY
LYMPHOMAS
NITRILES
OCCUPATIONAL DISEASES
PERSONNEL
WEST VIRGINIA
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FEDERAL REGION III
HAZARDS
HEMIC DISEASES
IMMUNE SYSTEM DISEASES
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ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOGENESIS
USA
560300* - Chemicals Metabolism & Toxicology