Effects of selected hydrazines on the early death rates of Enterobacter cloacae
The toxicity of hydrazine and several of its methylated derivatives has been studied in a variety of biological systems. The measurements used in these studies were concerned with growth kinetics, i.e., time and concentration parameters describing the growth cycle of bacteria. This method provided useful information but was not sufficiently sensitive at the extremes of cell culture density. Since the major indication of intoxication at the test concentrations used (10 ppm hydrazine (HZ); 20 ppm monomethylhydrazine (MMH); and 50 ppm 1,1-dimethylhydrazine (UDMH)) was an extension of the lag period, a possible mechanism of action is a random or selective killing of inoculum cells. Since experiments based on turbidimetric data can not address this aspect, the authors studied the early death rate kinetics of hydrazine-exposed cultures using a standard viable cell counting procedure as a more reliable quantitative method to enumerate cell death rate at low culture concentrations.
- Research Organization:
- Air Force Aerospace Medical Research Lab., Wright-Patterson, OH
- OSTI ID:
- 5021384
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Vol. 31:3
- Country of Publication:
- United States
- Language:
- English
Similar Records
Ozone oxidation of hydrazine fuels. Final report June-September 1978
Products of the neutralization of hydrazine fuels with hypochlorite: II
Related Subjects
30 DIRECT ENERGY CONVERSION
BACTERIA
POPULATION DYNAMICS
HYDRAZINE
BIOLOGICAL EFFECTS
NITROGEN COMPOUNDS
CELL KILLING
MICROORGANISMS
560302* - Chemicals Metabolism & Toxicology- Microorganisms- (-1987)
300500 - Fuel Cells