Developmental changes in the conversion rates of di(2-ethylhexyl)phthalate to monoethylhexyl phthalate in rats

Journal Article · Tue Jan 01 00:00:00 EST 1985 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398509530672· OSTI ID:5013360

Gollamudi, R; Hanumantha, R; Lawrence, W H; Autian, J

The activities of liver, lung, and kidney of rats of various age groups and that of placenta in hydrolyzing di(2-ethylhexyl) phthalate to mono(2-ethylhexyl) phthalate have been measured. Male and female rats of 45 d of age, neonatal rats within 12 h of parturition, and fetuses and placenta on d 19 of gestation were used. The liver was most active in all age groups; however, the lung and the kidney also had considerable activity. The tissues of the fetuses and the neonate had significant activity. The k/sub m/ values of the enzyme were 4mM in the neonatal liver and 5.9 mM in the adult liver.

• Research Organization: Univ. of Tennessee Center for the Health Sciences, Memphis
• OSTI ID: 5013360
• Journal Information: J. Toxicol. Environ. Health; (United States), Vol. 15:3-4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ENZYME ACTIVITY
PHTHALIC ACID ESTERS
ENZYMATIC HYDROLYSIS
ADULTS
AGE GROUPS
EXPERIMENTAL DATA
FETUSES
KIDNEYS
LIVER
LUNGS
NEONATES
PLACENTA
RATS
ANIMALS
BODY
CHEMICAL REACTIONS
DATA
DECOMPOSITION
DIGESTIVE SYSTEM
ESTERS
FETAL MEMBRANES
GLANDS
HYDROLYSIS
INFORMATION
LYSIS
MAMMALS
MEMBRANES
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
RESPIRATORY SYSTEM
RODENTS
SOLVOLYSIS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)