Epidemiologic approaches to assessing human cancer risk from consuming aquatic food resources from chemically contaminated water

Journal Article · Tue Jan 01 00:00:00 EST 1991 · Environmental Health Perspectives; (United States)

DOI:https://doi.org/10.2307/3430858· OSTI ID:5010726

Ozonoff, D ^[1]; Longnecker, M P ^[2]

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1. Boston Univ. School of Public Health, MA (United States)
2. UCLA School of Public Health, Los Angeles, CA (United States)

Epidemiologic approaches to assessing human cancer risk from contaminated waters must confront the problems of long latency and rarity of the end point (cancer). The latency problem makes determination of diet history more difficult, while the low frequency of cancer as an end point reduces the statistical power of the study. These factors are discussed in relation to the study designs most commonly employed in epidemiology. It is suggested that the use of biomarkers for persistent chemicals may be useful to mitigate the difficulty of determining exposure, while the use of more prevalent and timely end points, such as carcinogen-DNA adducts or oncogene proteins, may make the latency and rarity problems more tractable.

• OSTI ID: 5010726
• Journal Information: Environmental Health Perspectives; (United States), Vol. 90; ISSN 0091-6765
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CARCINOGENESIS
RISK ASSESSMENT
DNA ADDUCTS
BIOLOGICAL MARKERS
SEAFOOD
INGESTION
SEAWATER
CONTAMINATION
CARCINOGENS
EPIDEMIOLOGY
FISHES
LATENCY PERIOD
ONCOGENES
ADDUCTS
ANIMALS
AQUATIC ORGANISMS
FISH PRODUCTS
FOOD
GENES
HYDROGEN COMPOUNDS
INTAKE
OXYGEN COMPOUNDS
PATHOGENESIS
VERTEBRATES
WATER
560300* - Chemicals Metabolism & Toxicology