Effect of hyaluronic acid on postoperative intraperitoneal adhesion formation in the rat model
- Department of Obstetrics and Gynecology, University of British Columbia, Vancouver (Canada)
The aim of this study was to determine the effectiveness of hyaluronic acid solution in preventing intraperitoneal (IP) adhesions. The study design was prospective, randomized and blinded and involved 83 rats. Measured serosal injury was inflicted using a CO2 laser on the right uterine horn of the rat. Animals randomized to groups 1 and 2 received either 0.4% hyaluronic acid or its diluent phosphate-buffered saline (PBS) intraperitoneally before and after the injury. In groups 3 and 4, the same solutions were used only after the injury. Postoperative adhesions were assessed at second-look laparotomy. Histologic assessment of the fresh laser injury was carried out on uteri pretreated with hyaluronic acid, PBS, or nothing. Pretreatment with hyaluronic acid was associated with a significant reduction in postoperative adhesions and a significantly decreased crater depth. Hyaluronic acid appears to reduce postoperative IP adhesion formation by coating the serosal surfaces and decreasing the extent of initial tissue injury.
- OSTI ID:
- 5010267
- Journal Information:
- Fertility and Sterility; (United States), Vol. 56:3; ISSN 0015-0282
- Country of Publication:
- United States
- Language:
- English
Similar Records
Assessment of the subcutaneous degradation process of insoluble hyaluronic acid in rats
Intraperitoneal xenon for the detection of early intestinal ischemia: effect of ascites, adhesions, and misdirected injections
Related Subjects
HYALURONIC ACID
BIOLOGICAL EFFECTS
LASER RADIATION
UTERUS
PATHOLOGICAL CHANGES
CARBON DIOXIDE LASERS
RATS
AMINES
ANIMALS
BODY
CARBOHYDRATES
ELECTROMAGNETIC RADIATION
FEMALE GENITALS
GAS LASERS
LASERS
MAMMALS
MUCOPOLYSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
POLYSACCHARIDES
RADIATIONS
RODENTS
SACCHARIDES
VERTEBRATES
560400* - Other Environmental Pollutant Effects