Acute hepatotoxicity induced by hepatotoxins in Suncus murinus

Journal Article · Wed Jan 01 00:00:00 EST 1986 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398609530895· OSTI ID:5001555

Lin, S; Saito, H; Yohro, T; Shiga, J

A comparative study was conducted to contrast the hepatotoxicity of several chemicals in the musk shrew (Suncus murinus) versus other common laboratory species (mouse or rat), and the following results were obtained from serum enzymes (SGOT and SGPT) and histopathological findings of liver specimens. (1) The sensitivity of Suncus liver to CCl/sub 4/ was different from that of mouse liver. (2) The sensitivity of Suncus liver to ..beta..-D-galactosamine was weaker than that of rat liver. (3) The sensitivity of Suncus liver to ethanol was stronger than that of mouse liver. After a single oral administration of ethanol (99.5% v/v, 0.1 ml/50 g body weight), the gallbladder of Suncus became enlarged and dark blue in color. (4) A striking fatty degeneration was seen 24 h after a single ip administration of amethopterin at 50 mg/kg in Suncus liver.

• Research Organization: Univ. of Tokyo, Japan
• OSTI ID: 5001555
• Journal Information: J. Toxicol. Environ. Health; (United States), Vol. 18:4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
TOXICITY
CARBON TETRACHLORIDE
ETHANOL
LIVER
PATHOLOGICAL CHANGES
METHOTREXATE
SHREWS
SENSITIVITY
BIOLOGICAL MODELS
CRITICAL ORGANS
EXPERIMENTAL DATA
ALCOHOLS
ANIMALS
ANTIMETABOLITES
BODY
CHLORINATED ALIPHATIC HYDROCARBONS
DATA
DIGESTIVE SYSTEM
DRUGS
GLANDS
HALOGENATED ALIPHATIC HYDROCARBONS
HYDROXY COMPOUNDS
INFORMATION
MAMMALS
NUMERICAL DATA
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)