Parsing of genomic graffiti

Conference · Tue Dec 31 00:00:00 EST 1996

OSTI ID:495282

Tibbetts, C; Golden, J III; Torgersen, D ^[1]

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1. Vanderbilt Univ. School of Engineering, Nashville, TN (United States)

A focal point of modern biology is investigation of wide varieties of phenomena at the level of molecular genetics. The nucleotide sequences of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) define the ultimate resolution of this reductionist approach to understand the determinants of heritable traits. The structure and function of genes, their composite genomic organization, and their regulated expression have been studied in systems representing every class of organism. Many human diseases or pathogenic syndromes can be directly attributed to inherited defects in either the regulated expression, or the quality of the products of specific genes. Genetic determinants of susceptibility to infectious agents or environmental hazards are amply documented. Mapping and sequencing of the DNA molecules encoding human genes have provided powerful technology for pharmaceutical bioengineering and forensic investigations. From an alternative perspective, we may anticipate that voluminous archives of singular DNA sequences alone will not suffice to define and understand the functional determinants of genome organization, allelic diversity and evolutionary plasticity of living organisms. New insights will accumulate pertaining to human evolutionary origins and relationships of human biology to models based on other mammals. Investigators of population genetics and epidemiology now exploit the technology of molecular genetics to more powerfully probe variation within the human gene pool at the level of DNA sequences. 40 refs., 7 figs., 2 tabs.

• Research Organization: Minnesota Univ., Minneapolis, MN (United States). Inst. for Mathematics and Its Applications
• OSTI ID: 495282
• Report Number(s): CONF-9407205-Vol.81; TRN: 97:003312-0009
• Resource Relation: Conference: IMA summer program on molecular biology, Minneapolis, MN (United States), 5-29 Jul 1994; Other Information: PBD: 1996; Related Information: Is Part Of Genetic mapping and DNA sequencing; Speed, T. [ed.] [Univ. of California, Berkeley, CA (United States). Dept. of Statistics]; Waterman, M.S. [ed.] [Univ. of Southern California, Los Angeles, CA (United States). Dept. of Mathematics and Molecular Biology]; PB: 231 p.
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
44 INSTRUMENTATION
INCLUDING NUCLEAR AND PARTICLE DETECTORS
GENETIC MAPPING
RESOLUTION
GENES
DNA SEQUENCING
STRUCTURE-ACTIVITY RELATIONSHIPS
GENE REGULATION
GENE MUTATIONS
HEREDITARY DISEASES
GENETICS
EPIDEMIOLOGY
HUMAN POPULATIONS
POPULATION DYNAMICS
DNA SEQUENCERS
COST
AUTOMATION
QUALITY CONTROL
NUCLEOTIDES
RNA
DNA
BIOLOGICAL EVOLUTION
ELECTROPHORESIS