Comparison of human and mouse T-cell receptor variable gene segment subfamilies

Journal Article · Sun Oct 01 00:00:00 EDT 1995 · Immunogenetics

DOI:https://doi.org/10.1007/BF00172178· OSTI ID:471536

Clark, S P ^[1]; Arden, B; Kabelitz, D ^[2]; Mak, T W ^[3]

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1. Amgen Center, Thousand Oaks, CA (United States)
2. Paul-Ehrlich-Inst., Langen (Germany)
3. Amgen Inst., Toronto, Ontario (Canada)

Like the immunoglobulin Igh-V and Igk-V gene families, the human or mouse TCRV gene families may be grouped into subfamilies displaying {ge} 75% nucleic acid sequence similarity among their members. Systematic interspecies sequence comparisons reveal that most mouse Tcr-V subfamilies exhibit clear homology to human TCRV subfamilies ({ge}60% amino acid sequence similarity). Homologous paris of TCRV genes in mice and humans show higher sequence similarity than TCRV genes from different subfamilies within either species, indicating trans-species evolution of TCRV genes. Mouse and human homologues show conservation of their relative map order, particularly in the 3{prime} region and a similar sequential and developmentally programmed expression. When the V regions from both species were analyzed together, local length differences and conserved residues in the loop regions were revealed, characteristic of each of the four TCRV families. 31 refs., 4 figs.

• Sponsoring Organization: USDOE
• OSTI ID: 471536
• Journal Information: Immunogenetics, Vol. 42, Issue 6; Other Information: PBD: Oct 1995
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
99 MATHEMATICS
COMPUTERS
INFORMATION SCIENCE
MANAGEMENT
LAW
MISCELLANEOUS
GENES
GENE MUTATIONS
STANDARDIZED TERMINOLOGY
GENETIC MAPPING
DNA SEQUENCING
STRUCTURE-ACTIVITY RELATIONSHIPS
DATA BASE MANAGEMENT
AMINO ACID SEQUENCE
BIOLOGICAL EVOLUTION
GENE REGULATION
LYMPHOCYTES
RECEPTORS
MICE
CORRELATIONS
GENETIC VARIABILITY
MAN
NUCLEIC ACIDS