Effects of low frequency pulsed electrical current on keratinocytes in vitro

Journal Article · Thu May 01 00:00:00 EDT 1997 · Bioelectromagnetics

DOI:https://doi.org/10.1002/(SICI)1521-186X(1997)18:3<250::AID-BEM8>3.0.CO;2-1· OSTI ID:462571

Hinsenkamp, M; Jercinovic, A ^[1]

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1. Hopital Erasme-Universite Libre de Bruxelles, Brussels (Belgium)

The effects of low frequency pulsed electrical current on epidermal repair in vitro were examined. Charge-balanced current stimuli proposed for chronic wound treatment were tested on skin keratinocytes cultured at an air-liquid interface on dead human dermis. Results imply that the balance between proliferation and differentiation in electrically treated samples is significantly modified in favor of differentiation. More advanced differentiation, shown through epidermal histology, was obtained in cultures exposed to electrical current, whereas the culture growth, the result of keratinocyte migration and proliferation, was greater in control samples.

• Sponsoring Organization: Commission of the European Communities, Brussels (Belgium)
• OSTI ID: 462571
• Journal Information: Bioelectromagnetics, Vol. 18, Issue 3; Other Information: PBD: 1997
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
ELECTROMAGNETIC FIELDS
EPIDERMIS
WOUNDS
BIOLOGICAL EFFECTS
BIOLOGICAL REPAIR
HEALING
CELL PROLIFERATION
MAN