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Title: Effects of age of serotonin 5-HT2 receptors in cocaine abusers and normal subjects

We measured the effect of age on serotonin 5-HT2 receptor availability and compared it with the effects on dopamine D2 receptors on 19 chronic cocaine abusers (35.2{plus_minus}9.8 years, range 18-54 years old) and 19 age matched normal controls using positron emission tomography (PET) and F-18 N-methylspiperone (NMS). 5-HT2 Receptor availability was measure din frontal (FR), occipital (OC), cingulate (CI) and orbitofrontal (OF) cortices using the ratio of the distribution volume in the region of interest to that in the cerebelium (CB) which is a function of Bmax/Kd. D2 receptor availability in the basal ganglia was measured using the {open_quotes}ratio index{close_quotes} (slope of striatum/CB versus time over 180 min of the scan) which is a function of Bmax. 5-HT2 Receptor availability differed among regions and were as follows: CI>OF>OC>FC.5-HT2 Receptor availability decreased significantly with age. This effect was more accentuated for 5-HT2 receptor availability in FR than in OC(df=1, p<0.025). Striatal dopamine D2 receptors were also found to decrease significantly with age (r=0.63, p<0.007). In a given subject, D2 receptor availability was significantly correlated with 5-HT2 receptor availability in FR (r=0.51, p<0.035) but not in OC. The values for 5-HT2 receptor availability were not different in normal subjects and cocaine abusers.more » These results document a decline in 5-HT2 and D2 receptors with age and document an association between frontal 5-HT2 and striatal D2 receptor availability. These results did not show any changes in 5-HT2 receptor availability in cocaine abusers as compared to control subjects.« less
Authors:
; ;  [1]
  1. Brookhaven National Laboratory, Upton, NY (United States) [and others
Publication Date:
OSTI Identifier:
441579
Report Number(s):
CONF-950603-
Journal ID: JNMEAQ; ISSN 0161-5505; TRN: 96:002093-0003
DOE Contract Number:
AC02-76CH00016
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of Nuclear Medicine; Journal Volume: 36; Journal Issue: Suppl.5; Conference: 42. annual meeting of the Society of Nuclear Medicine, Minneapolis, MN (United States), 12-15 Jun 1995; Other Information: PBD: May 1995
Research Org:
Brookhaven National Laboratory (BNL), Upton, NY
Country of Publication:
United States
Language:
English
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; COCAINE; BIOCHEMISTRY; DOPAMINE; STIMULATION; RECEPTORS; SEROTONIN; AGE DEPENDENCE; POSITRON COMPUTED TOMOGRAPHY; DRUG ABUSE