Lethal or protective effects of prolonged treatment with hypoxic cell sensitizers
- Karolinska Inst., Stockholm (Sweden). Dept. of Medical Radiation Physics
AK-2123 [N-(2-methoxyethyl)-2-(3-nitro-1-triazolyl)acetamide] is a hypoxic cell radiosensitizer which is currently being tested in several oncology clinics and which has a lower toxicity than misonidazole (MISO) in vivo. The positive experiences reported recently certainly warrant further clinical evaluations. The experimental observations reported so far need further experimental studies to clarify the sensitization mechanism, especially as recent intratumoral strategies used in the clinical administration of the sensitizers can result in a large local concentration of the drug that may persist for a prolonged period of time between and after radiation exposures. Model experiments in vitro using V79 cells were performed with AK-2123 under these conditions. Misonidazole (MISO) and metronidazole (METRO), well known hypoxic cell radiosensitizers, were used for comparison of the effects. Clonogenic survival and induction and repair of DNA damage were used as end-points.
- OSTI ID:
- 400747
- Report Number(s):
- CONF-9410280-; ISBN 0-935470-90-5; TRN: 96:030269
- Resource Relation:
- Conference: International workshop on radiation damage in DNA: relationships at early times, Gleneden, OR (United States), 1-6 Oct 1994; Other Information: PBD: 1995; Related Information: Is Part Of Radiation damage in DNA: Structure/function relationships at early times; Fuciarelli, A.F. [ed.] [Pacific Northwest Lab., Richland, WA (United States). Biology and Chemistry Dept.]; Zimbrick, J.D. [ed.] [National Academy of Sciences, Washington, DC (United States). National Research Council]; PB: 460 p.
- Country of Publication:
- United States
- Language:
- English
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