Localization of the gene (LAMA4) to chromosome 6q21 and isolation of a partial cDNA encoding a variant laminin A chain
- MRC Clinical Research Centre, Middlesex (United Kingdom); and others
Laminin is a basement membrane glycoprotein composed of three nonidentical chains, A, B1, and B2. Variant chains such as merosin and S-laminin have been found in different tissues. The authors have isolated a cDNA encoding a novel laminin A variant that hybridizes to a 6.45-kb mRNA. Using amplification of genomic DNA and flow-sorted chromosomes they have assigned the gene (LAMA4) for this new laminin A variant to chromosome 6. Fluorescence in situ hybridization of a YAC clone further localized the gene to 6q21. 19 refs., 2 figs.
- OSTI ID:
- 255192
- Journal Information:
- Genomics, Vol. 22, Issue 1; Other Information: PBD: 1 Jul 1994
- Country of Publication:
- United States
- Language:
- English
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