Cloning of the human skeletal muscle {alpha}{sub 1} subunit of the dihydropyridine-sensitive L-type calcium channel (CACNL1A3)
- Univ. of Wisconsin, Madison, WI (United States)
Skeletal muscle contraction is initiated by release of calcium stored in the sarcoplasmic reticulum in response to membrane depolarization transduced by the L-type voltage-dependent calcium channels (VDCCs) present in the transverse tubule. The L-type VDCC purified from rabbit skeletal muscle transverse tubules is a pentamer composed of {alpha}{sub 1}, {alpha}{sub 2}, {Beta},{delta}, and {gamma} subunits. Here, we report the sequence of the human {alpha}{sub 1} subunit. 8 refs., 1 fig.
- OSTI ID:
- 241053
- Journal Information:
- Genomics, Vol. 24, Issue 3; Other Information: PBD: Dec 1994
- Country of Publication:
- United States
- Language:
- English
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