Experimental evaluation of electrical conductivity imaging of anisotropic brain tissues using a combination of diffusion tensor imaging and magnetic resonance electrical impedance tomography
- Department of Pharmacology, Chung-Ang University, Seoul 06974 (Korea, Republic of)
- Department of East-West Medical Science, Kyung Hee University, Yongin 17104 (Korea, Republic of)
- Department of Mathematics, Konkuk University, Seoul 05029 (Korea, Republic of)
Anisotropy of biological tissues is a low-frequency phenomenon that is associated with the function and structure of cell membranes. Imaging of anisotropic conductivity has potential for the analysis of interactions between electromagnetic fields and biological systems, such as the prediction of current pathways in electrical stimulation therapy. To improve application to the clinical environment, precise approaches are required to understand the exact responses inside the human body subjected to the stimulated currents. In this study, we experimentally evaluate the anisotropic conductivity tensor distribution of canine brain tissues, using a recently developed diffusion tensor-magnetic resonance electrical impedance tomography method. At low frequency, electrical conductivity of the biological tissues can be expressed as a product of the mobility and concentration of ions in the extracellular space. From diffusion tensor images of the brain, we can obtain directional information on diffusive movements of water molecules, which correspond to the mobility of ions. The position dependent scale factor, which provides information on ion concentration, was successfully calculated from the magnetic flux density, to obtain the equivalent conductivity tensor. By combining the information from both techniques, we can finally reconstruct the anisotropic conductivity tensor images of brain tissues. The reconstructed conductivity images better demonstrate the enhanced signal intensity in strongly anisotropic brain regions, compared with those resulting from previous methods using a global scale factor.
- OSTI ID:
- 22611533
- Journal Information:
- AIP Advances, Vol. 6, Issue 6; Other Information: (c) 2016 Author(s); Country of input: International Atomic Energy Agency (IAEA); ISSN 2158-3226
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ANIMAL TISSUES
ANISOTROPY
BIOMEDICAL RADIOGRAPHY
BRAIN
CURRENTS
DIFFUSION
DISTRIBUTION
ELECTRIC CONDUCTIVITY
ELECTROMAGNETIC FIELDS
EXTRACELLULAR SPACE
FLUX DENSITY
INTERACTIONS
MAGNETIC FLUX
MAGNETIC RESONANCE
MOBILITY
MOLECULES
STIMULATION
THERAPY
TOMOGRAPHY
WATER