Novel hydrogen sulfide-releasing compound, S-propargyl-cysteine, prevents STZ-induced diabetic nephropathy

Journal Article · Fri May 13 00:00:00 EDT 2016 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/J.BBRC.2016.03.154· OSTI ID:22596381

Qian, Xin ^[1]; Li, Xinghui ^[2]; Ma, Fenfen; Luo, Shanshan ^[1]; Ge, Ruowen ^[3]; Zhu, Yizhun ^[1]

---

1. Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai (China)
2. Departments of Physiology and Pathophysiology, Shanghai College of Medicine, Fudan University, Shanghai (China)
3. Departmentof Biological Sciences, National University of Singapore (Singapore)

In this work, we demonstrated for the first time that S-propargyl-cysteine (SPRC, also named as ZYZ-802), a novel hydrogen sulfide (H{sub 2}S)-releasing compound, had renoprotective effects on streptozotocin (STZ)-induced diabetic kidney injury. SPRC treatment significantly reduced the level of creatinine, kidney to body weight ratio and in particular, markedly decreased 24-h urine microalbuminuria excretion. SPRC suppressed the mRNA expression of fibronectin and type IV collagen. In vitro, SPRC inhibited mesangial cells over-proliferation and hypertrophy induced by high glucose. Additionally, SPRC attenuated inflammation in diabetic kidneys. SPRC also reduced transforming growth factor β1 (TGF-β1) signaling and expression of phosphorylated Smad3 (p-Smad3) pathway. Moreover, SPRC inhibited phosphorylation of ERK, p38 protein. Taken together, SPRC was demonstrated to be a potential therapeutic candidate to suppress diabetic nephropathy. - Highlights: • We synthesized a novel hydrogen sulfide-releasing compound, S-propargyl-cysteine (SPRC). • SPRC was preliminarily demonstrated to prevent STZ-induced diabetic nephropathy (DN). • SPRC may exert potential therapeutic candidate to suppress DN.

• OSTI ID: 22596381
• Journal Information: Biochemical and Biophysical Research Communications, Vol. 473, Issue 4; Other Information: Copyright (c) 2016 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
ALBUMINURIA
COLLAGEN
CREATININE
CYSTEINE
EXCRETION
FIBROSIS
GLUCOSE
GROWTH FACTORS
HYDROGEN SULFIDES
HYPERTROPHY
IN VITRO
INFLAMMATION
INJURIES
KIDNEYS
MESSENGER-RNA
PHOSPHORYLATION
STREPTOZOCIN
URINE