Simulation of multi-photon emission isotopes using time-resolved SimSET multiple photon history generator

Conference · Wed Jul 01 00:00:00 EDT 2015

DOI:https://doi.org/10.1109/ANIMMA.2015.7465629· OSTI ID:22531368

Chiang, Chih-Chieh; Lin, Hsin-Hon; Lin, Chang-Shiun; Chuang, Keh-Shih ^[1]; Jan, Meei-Ling ^[2]

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1. Department of Biomedical Engineering and Environmental Sciences, National Tsing-HuaUniversity, Hsinchu, Taiwan (China)
2. Health Physics Division, Institute of Nuclear Energy Research, Atomic Energy Council, Taoyuan, Taiwan (China)

Abstract-Multiple-photon emitters, such as In-111 or Se-75, have enormous potential in the field of nuclear medicine imaging. For example, Se-75 can be used to investigate the bile acid malabsorption and measure the bile acid pool loss. The simulation system for emission tomography (SimSET) is a well-known Monte Carlo simulation (MCS) code in nuclear medicine for its high computational efficiency. However, current SimSET cannot simulate these isotopes due to the lack of modeling of complex decay scheme and the time-dependent decay process. To extend the versatility of SimSET for simulation of those multi-photon emission isotopes, a time-resolved multiple photon history generator based on SimSET codes is developed in present study. For developing the time-resolved SimSET (trSimSET) with radionuclide decay process, the new MCS model introduce new features, including decay time information and photon time-of-flight information, into this new code. The half-life of energy states were tabulated from the Evaluated Nuclear Structure Data File (ENSDF) database. The MCS results indicate that the overall percent difference is less than 8.5% for all simulation trials as compared to GATE. To sum up, we demonstrated that time-resolved SimSET multiple photon history generator can have comparable accuracy with GATE and keeping better computational efficiency. The new MCS code is very useful to study the multi-photon imaging of novel isotopes that needs the simulation of lifetime and the time-of-fight measurements. (authors)

• Research Organization: Institute of Electrical and Electronics Engineers - IEEE, 3 Park Avenue, 17th Floor, New York, N.Y. 10016-5997 (United States)
• OSTI ID: 22531368
• Report Number(s): ANIMMA-2015-IO-320; TRN: US16V0355102309
• Resource Relation: Conference: ANIMMA 2015: 4. International Conference on Advancements in Nuclear Instrumentation Measurement Methods and their Applications, Lisboa (Portugal), 20-24 Apr 2015; Other Information: Country of input: France; 24 Refs.
• Country of Publication: United States
• Language: English

Related Subjects

07 ISOTOPES AND RADIATION SOURCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ACCURACY
BILE ACIDS
BIOMEDICAL RADIOGRAPHY
COMPARATIVE EVALUATIONS
COMPUTERIZED SIMULATION
EFFICIENCY
EMISSION
HALF-LIFE
INDIUM 111
LIFETIME
MONTE CARLO METHOD
MULTI-PHOTON PROCESSES
PHOTONS
S CODES
SELENIUM 75
TIME DEPENDENCE
TIME RESOLUTION
TIME-OF-FLIGHT METHOD
TOMOGRAPHY