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Title: Gadolinia nanofibers as a multimodal bioimaging and potential radiation therapy agent

Continuous bead-free C-type cubic gadolinium oxide (Gd{sub 2}O{sub 3}) nanofibers 20-30 μm long and 40-100 nm in diameter were sintered by sol-gel calcination assisted electrospinning technique. Dipole-dipole interaction of neighboring Gd{sup 3+} ions in nanofibers with large length-to-diameter aspect ratio results in some kind of superparamagnetic behavior: fibers are magnetized twice stronger than Gd{sub 2}O{sub 3} powder. Being compared with commercial Gd-DTPA/Magnevist{sup ®}, Gd{sub 2}O{sub 3} diethyleneglycol-coated (Gd{sub 2}O{sub 3}-DEG) fibers show high 1/T{sub 1} and 1/T{sub 2} proton relaxivities. Intense room temperature photoluminescence, high NMR relaxivity and high neutron scattering cross-section of {sup 157}Gd nucleus promise to integrate Gd{sub 2}O{sub 3} fibers for multimodal bioimaging and neutron capture therapy.
Authors:
 [1] ;  [2] ;  [3] ;  [1] ;  [2] ;  [4]
  1. KTH Royal Institute of Technology, SE-164 40 Stockholm-Kista (Sweden)
  2. (Sweden)
  3. (Russian Federation)
  4. Racah Institute of Physics, Hebrew University of Jerusalem, 91904 Jerusalem (Israel)
Publication Date:
OSTI Identifier:
22488566
Resource Type:
Journal Article
Resource Relation:
Journal Name: AIP Advances; Journal Volume: 5; Journal Issue: 5; Other Information: (c) 2015 Author(s); Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; 77 NANOSCIENCE AND NANOTECHNOLOGY; ASPECT RATIO; CALCINATION; COMPARATIVE EVALUATIONS; CROSS SECTIONS; DIPOLES; FIBERS; GADOLINIUM 157; GADOLINIUM IONS; GADOLINIUM OXIDES; INTERACTIONS; NANOFIBERS; NEUTRON CAPTURE THERAPY; NEUTRON DIFFRACTION; NUCLEAR MAGNETIC RESONANCE; PHOTOLUMINESCENCE; POWDERS; PROTONS; SOL-GEL PROCESS; SUPERPARAMAGNETISM