Gadolinia nanofibers as a multimodal bioimaging and potential radiation therapy agent

Journal Article · Fri May 15 00:00:00 EDT 2015 · AIP Advances

DOI:https://doi.org/10.1063/1.4919810· OSTI ID:22488566

Jalalian, A. ^[1]; Tsindlekht, M. I. ^[2]

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1. KTH Royal Institute of Technology, SE-164 40 Stockholm-Kista (Sweden)
2. Racah Institute of Physics, Hebrew University of Jerusalem, 91904 Jerusalem (Israel)

Continuous bead-free C-type cubic gadolinium oxide (Gd{sub 2}O{sub 3}) nanofibers 20-30 μm long and 40-100 nm in diameter were sintered by sol-gel calcination assisted electrospinning technique. Dipole-dipole interaction of neighboring Gd{sup 3+} ions in nanofibers with large length-to-diameter aspect ratio results in some kind of superparamagnetic behavior: fibers are magnetized twice stronger than Gd{sub 2}O{sub 3} powder. Being compared with commercial Gd-DTPA/Magnevist{sup ®}, Gd{sub 2}O{sub 3} diethyleneglycol-coated (Gd{sub 2}O{sub 3}-DEG) fibers show high 1/T{sub 1} and 1/T{sub 2} proton relaxivities. Intense room temperature photoluminescence, high NMR relaxivity and high neutron scattering cross-section of {sup 157}Gd nucleus promise to integrate Gd{sub 2}O{sub 3} fibers for multimodal bioimaging and neutron capture therapy.

• OSTI ID: 22488566
• Journal Information: AIP Advances, Vol. 5, Issue 5; Other Information: (c) 2015 Author(s); Country of input: International Atomic Energy Agency (IAEA); ISSN 2158-3226
• Country of Publication: United States
• Language: English

Related Subjects

36 MATERIALS SCIENCE
77 NANOSCIENCE AND NANOTECHNOLOGY
ASPECT RATIO
CALCINATION
COMPARATIVE EVALUATIONS
CROSS SECTIONS
DIPOLES
FIBERS
GADOLINIUM 157
GADOLINIUM IONS
GADOLINIUM OXIDES
INTERACTIONS
NANOFIBERS
NEUTRON CAPTURE THERAPY
NEUTRON DIFFRACTION
NUCLEAR MAGNETIC RESONANCE
PHOTOLUMINESCENCE
POWDERS
PROTONS
SOL-GEL PROCESS
SUPERPARAMAGNETISM